P-19 Toxicity and outcome of definitive chemoradiotherapy for elderly patients with esophageal cancer

The efficacy and safety of definitive chemoradiotherapy (dCRT) for older patients with unresectable esophageal cancer (EC) have not been fully understood yet. aim our study was to evaluate the outcome toxicity in (65 years over) EC treated dCRT. From 4 Georgian centers a radiation oncology department, we identified 44 elderly suitable according criteria. Overall survival estimated from beginning treatment scored using CTCAE 5.0 median age 70.0 (range, 65-83 years), male predominance (77,3%) 59% were performance status ECOG 1. Because significant dysphagia (Grade 3-4) 9 underwent intervention (stenting or gastrostomy) before More than 2/3 squamous cell histological type (77,3%). Localization tumor equally distributed between middle lower parts esophagus (38.6%) 26 (59,1%) length more 5cm. majority had stage III disease (61,4%). Median 16.0 months (95% CI, 0-35.9). at 12months 24 53,7% 43,6% respectively. 15 (34%) are alive 2.1 5.4 after treatment. Statistically difference (p =0.011) OS found who received full (not reached) versus non-full dose RT 9.0 month 2.79-15.2). Additional analysis subgroups revealed elder subgroup (>75) highest OS, compared younger (65-70) intermediate groups (71-75) (p=0.001). most common adverse event Grade 3-4 leukopenia (43.2%) anemia (29.5%) esophagitis (27.3%) cases. results support feasibility dCRT carefully selected patients. Survival correlated complete therefore accurate selection is crucial better long-term survival. There an emerging need characterize "functional age" tailor decisions stratify outcomes based on factors other chronologic